Anti-ageing and better immunity - NL-011

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Here is a brief introduction to Resveratrol:

Resveratrol

The French Paradox is an idea that has been studied by many. It suggests that French people have a longer life expectancy and are less likely to suffer from coronary heart disease or obesity, despite consuming high-fat diets. Scientists believe that the consumption of red wine in France could be a factor. This beverage contains resveratrol, which is a polyphenolic compound that has been linked to improved heart health and longer lifespans.

In recent years, researchers have looked into the potential of resveratrol to slow down the ageing process and fend off age-related ailments such as type 2 diabetes, Alzheimer's, cardiovascular disease, and stroke. As people get older, their risk for chronic diseases like these tend to rise significantly.

What is Resveratrol?

A fat-soluble compound known as resveratrol is mainly discovered in the skins of red and purple grapes. It can also be found in certain berries including blueberries, mulberries, cranberries and raspberries, peanuts, pistachio, green tea and chocolate.

Polyphenols, of which resveratrol is a type known as a phytoalexin, are compounds that plants produce as a response to certain conditions such as drought, fungal infection, or UV radiation. This polyphenol functions to protect the plant from both external and internal stressors.

According to researchers, humans could also enjoy the protective advantages of resveratrol when they consume it. Studies demonstrate that the compound may possess great anti-ageing benefits. Furthermore, it has been found to have anti-inflammatory and antioxidant properties, as well as help maintain normal cell replication.

Resveratrol possesses many properties that, taken together, make it an effective anti-aging agent. Research indicates that it can help to protect against Alzheimer's, diabetes, obesity, myocardial infarction and stroke.

How Resveratrol fights cellular ageing?

Antioxidant and anti-inflammatory properties

The potent antioxidant properties of resveratrol protect cells and tissues from oxidative damage by scavenging free radicals and limiting their formation. This same compound also obstructs the synthesis of certain chemicals that cause inflammation in the body.

Resveratrol possesses anti-oxidant and anti-inflammatory qualities that not only benefit the ageing process, but also benefit heart health and vascular health. It helps protect blood vessels from oxidation, reduces cholesterol, and reduces the chance of clot formation, thus avoiding the occurrence of heart attacks and strokes.

Resveratrol activates Sirtuins

Resveratrol is often talked about when it comes to the science of ageing, not just because of its impressive antioxidant properties, but also due to another intriguing feature.

In 2013, research revealed that resveratrol directly activates sirtuins, particularly SIRT1. This is a major way by which it can provide anti-aging effects. Sirtuins are the type of enzymes that are in charge of and regulate multiple biological processes related to ageing – including inflammation, stress tolerance, mitochondrial activities, metabolism and DNA repair.

David Sinclair, Harvard Medical School professor of genetics and lead author on the paper, remarked that " In the history of pharmaceuticals, there has never been a drug that binds to a protein to make it run faster in the way that resveratrol activates SIRT1. Almost all drugs either slow or block them.”

Mitochondria are components of cells that are responsible for generating energy for activities such as replication, growth, repair, and sustenance. Unfortunately, the process of energy production also leads to the formation of reactive oxygen species which are known to damage cellular and mitochondrial DNA. These two factors, oxidative damage and mitochondrial dysfunction, are thought to be major contributors to the ageing process.

The process of ageing can be delayed due to resveratrol which encourages mitochondrial biogenesis. This helps to create increased energy while decreasing the production of free radicals and oxidative damage. Its intricate and complex mechanisms contribute to overall health.

Limiting calorie intake has been long recognized as a way to prolong life and preserve overall well-being. Research has revealed that sirtuins are the key players in the anti-ageing benefits of calorie restriction. Resveratrol, meanwhile, has been identified to act in a similar fashion, activating sirtuins to achieve the same outcomes in terms of longevity and health span.